Levocarnitine 500mg/ml (L-Carnitine)

30mL

Levocarnitine 500mg/ml
Levocarnitine injections are typically administered intravenously (IV). Here are the general steps for administration:
Dosage: The recommended dose is usually 50 mg/kg, which can be given as a slow bolus injection over 2-3 minutes or by infusion [10][11].
Preparation: The injection is prepared in a sterile environment. The solution contains 200 mg of levocarnitine per mL [4].
Administration:
Bolus Injection: Administered slowly over 2-3 minutes.
Infusion: Can be given over a longer period, often in cases of severe metabolic crisis. The infusion rate and frequency depend on the patient’s condition [10][11].

Fatty Acid Transport: Levocarnitine acts as a carrier molecule, transporting long-chain fatty acids across the inner mitochondrial membrane [5]. This process is essential for the β-oxidation of fatty acids, which generates ATP, the primary energy currency of cells [6].
Acyl Group Export: It helps export acyl groups from subcellular organelles and cells to urine, preventing the accumulation of toxic concentrations [5].
Regulation of Metabolic Pathways: By maintaining the acetyl-CoA/CoA ratio in cells, levocarnitine regulates the activity of pyruvate dehydrogenase, an enzyme critical for converting pyruvate into acetyl-CoA, thereby linking glycolysis and the citric acid cycle [6].

Allergy: Do not use levocarnitine if you have a known allergy to it or any of its components [7].
Seizures: It may exacerbate seizure disorders, so it should be used with caution in individuals with a history of seizures [4].
Kidney Disease: If you have kidney disease or are on dialysis, levocarnitine should be used under strict medical supervision [7].
Diabetes and Alcohol Dependence: Liquid preparations may contain sugar and/or alcohol, which require caution if you have diabetes, alcohol dependence, or liver disease [7].
Regular Monitoring: Blood tests and monitoring of vital signs are often necessary during treatment to ensure safety and efficacy [4].
 

Gastrointestinal Issues: nausea, vomiting, diarrhea, abdominal pain or cramps [4].
Nervous System: Headache, dizziness [4].
Other:Body odor (often described as a “fishy” smell) Muscle pain or weakness [7].
Serious Side Effects:
Allergic Reactions: Hives, difficulty breathing, swelling of the face, lips,tongue, or throat4.
Seizures: Increased frequency or severity of seizures, especially in individuals with a history of seizure disorders [4].
Cardiovascular Issues: High blood pressure, fast heartbeat [4].
 

Pregnancy and Breastfeeding: Consult your doctor before using levocarnitine if you are pregnant or breastfeeding [4].

Temperature: Store at room temperature, between 15°C and 30°C (59°F and 86°F) [8].
Environment: Keep the medication in a closed container, away from heat, moisture, and direct light [4][8].
Freezing: Do not freeze the medication [9].
Children: Keep out of the reach of children [9].
Expiration: Do not use outdated medicine or medicine that is no longer needed [9].
 

1. my.cleveland.org  2. mayoclinic.org 3. msn.com 
4. drugs.com 5. go.drugbank.com 6. jissn.biomedcentral.com
7. webmd.com 8. medicinenet.com 9. mayoclinic.org
10. rxlist.com 11. dailymed.nlm.nih.gov