L-Arginine Injection
100 mg/ml
Size: 30 mLL-Arginine is a conditionally essential amino acid and an endogenous substrate for nitric oxide synthesis [1][2]. As a critical metabolic intermediate, L-Arginine plays a central role in the urea cycle for ammonia detoxification and is fundamentally required for the synthesis of proteins, creatine, and polyamines [1][2].
Sterile L-Arginine HCl Injection is formulated to support healthcare providers with a sterile parenteral amino acid solution for intravenous administration in clinical settings. In formal clinical practice, intravenous Arginine Hydrochloride is utilized primarily as a diagnostic aid for assessing pituitary growth hormone reserve through stimulation of human growth hormone (HGH) release [4][3].
More About This Product
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• Concentration: 100 mg/mL
• Volume: 30 mL Multi-Dose Vial
• Route of Administration: Intravenous (IV) Use.
L-Arginine HCl is formulated as a sterile, hypertonic parenteral solution (Calculated Osmolarity: ~1148 mOsm/L). Due to its hypertonicity, it must be administered slowly via IV infusion to minimize venous irritation [3]. Adherence to strict aseptic technique is required during vial puncture and administration.
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L-Arginine exerts distinct endocrine and vascular effects:
Pituitary Stimulation: Intravenous administration of L-Arginine stimulates the pituitary gland to release human growth hormone (HGH), though the precise mechanism of this diagnostic response is not completely understood [4].
Vascular Physiology: L-Arginine serves as the endogenous substrate for nitric oxide synthase, resulting in the production of nitric oxide (NO), an important mediator of vascular smooth muscle relaxation and endothelial function [1][2].
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Contraindications: L-Arginine is contraindicated in patients with known hypersensitivity to L-Arginine or any component of the formulation. Due to the presence of benzyl alcohol (2%) as a preservative in this specific multi-dose formulation, it is strictly contraindicated for use in neonates and low-birth-weight infants [3].
Precautions: Because this formulation contains hydrochloride (HCl), IV administration can induce hyperchloremic metabolic acidosis; clinicians should evaluate acid-base balance prior to and during administration. L-Arginine should be used with extreme caution in patients with severe renal disease or anuria due to the risk of developing severe hyperkalemia [3][4].
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The following medications may influence therapeutic response or physiological stability:
Potassium-Sparing Diuretics: Concurrent administration significantly increases the risk of severe hyperkalemia, particularly in patients with underlying renal dysfunction [3].
Vasodilators & Antihypertensives: Additive vasodilatory effects may occur when co-administered with nitrates or PDE5 inhibitors, potentially leading to clinical hypotension [1].
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Parenteral administration is generally well-tolerated when infused at appropriate clinical rates. Reported adverse reactions may include [3][4]:
Local/Injection Site: Venous irritation, phlebitis, or localized erythema at the infusion site (primarily associated with the hypertonicity of the solution and rapid infusion).
Cardiovascular: Hypotension; transient flushing.
Gastrointestinal: Nausea, vomiting.
Neurological/Systemic: Headache; numbness; allergic reactions; anaphylaxis (rare).
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Pregnancy: Reproduction studies have been performed in rabbits and mice at doses up to 12 times the human dose and have revealed no evidence of impaired fertility or fetal harm. However, adequate and well-controlled studies in pregnant women have not been conducted. Because animal reproduction studies are not always predictive of human response, L-Arginine should be administered during pregnancy only when the potential benefit justifies the potential risk [3][4].
Lactation: It is not known whether parenterally administered L-Arginine is excreted in human breast milk. Caution is advised when administered to nursing individuals [3].
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Store at USP Controlled Room Temperature 20° to 25°C (68° to 77°F). Protect from light. Do not freeze [3]. Store in the original carton until time of use. Safely discard any unused portion after the designated beyond-use date (BUD) in accordance with standard facility protocols for medical waste. Do not flush unused medications [3].
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[1] Boger RH. The pharmacodynamics of L-arginine. J Nutr. 2007; 137(6 Suppl 2): 1650S-1655S.
[2] StatPearls. L-Arginine. Treasure Island (FL): StatPearls Publishing.
[3] U.S. Food and Drug Administration (FDA). Arginine Hydrochloride Injection Professional Prescribing Information. DailyMed.
[4] Pfizer Inc. R-Gene 10 (Arginine Hydrochloride Injection) Professional Prescribing Information.
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This information is intended for healthcare professionals. Refer to the full prescribing information for complete safety and prescribing details.
